Nonsteroidal Anti-Inflammatory Drugs and the Risk of Periodontitis Among Adults With Osteoarthritis: A Target Trial Emulation - PubMed
2 hours ago
- #Periodontitis
- #Osteoarthritis
- #NSAIDs
- The study emulated target trials to compare the 5-year risk of periodontitis in adults with osteoarthritis initiating NSAIDs versus acetaminophen, using US electronic health records from 1995-2019.
- No significant difference in 5-year risk of periodontitis was found between NSAIDs and acetaminophen users, with a risk difference of 0.13% (95% CI: -0.32%, 0.58%).
- Subgroup analysis by NSAID COX selectivity (non-selective and preferential COX-2 inhibitors) showed similar results, indicating no differential effect on periodontitis risk based on COX selectivity.
- A negative control outcome analysis for dental caries also showed no significant risk difference (-0.27%, 95% CI: -1.01%, 0.50%), supporting the absence of bias in the study findings.
- The study concluded that initiating NSAIDs does not influence the 5-year risk of periodontitis compared to acetaminophen in adults with osteoarthritis, aligning with inconclusive evidence from smaller studies on NSAIDs as adjuncts in periodontitis treatment.