Shared pathophysiological mechanisms between diabetes and calcific aortic valve disease: an immunometabolic perspective - PubMed
3 hours ago
- #immunometabolism
- #calcific aortic valve disease
- #diabetes
- Diabetes increases the risk and severity of calcific aortic valve disease (CAVD) independently of other cardiovascular risk factors.
- Seven interconnected pathways link diabetes to CAVD, including hyperglycemia-induced cell changes, inflammation, oxidative stress, and osteogenic reprogramming.
- These mechanisms promote valvular inflammation, matrix remodeling, and ectopic ossification, accelerating calcification.
- Potential therapies for diabetic CAVD include metformin, SGLT2 inhibitors, and anti-inflammatory drugs targeting NLRP3-IL-1β.
- Integrated biomarkers and valve-focused clinical trials are needed to translate these insights into effective treatments.