Cannabidiol induces apoptosis and autophagy via STAT3 and NF-κB inhibition and synergistically enhances paclitaxel efficacy in non-small cell lung cancer - PubMed
3 hours ago
- #non-small cell lung cancer
- #cannabidiol
- #STAT3/NF-κB signaling
- Cannabidiol (CBD) reduces cell viability in non-small cell lung cancer (NSCLC) cells while showing less cytotoxicity in normal lung cells.
- CBD induces apoptosis and autophagy by inhibiting STAT3 and NF-κB signaling, affecting both constitutive and inducible activation.
- CBD synergistically enhances the efficacy of paclitaxel in vitro and in vivo, leading to significant tumor suppression in a xenograft mouse model without affecting body weight.
- Tumor tissue analyses confirm that CBD downregulates phosphorylated STAT3 and p65, reduces Ki-67 expression, and increases cleaved PARP and LC3 II levels.