Multivalent antibody-based conjugates as new tools for tailored modulation of G protein-coupled receptors - PubMed
3 hours ago
- #GPCR modulation
- #antibody conjugates
- #nanobodies
- G protein-coupled receptors (GPCRs) are common drug targets, and antibodies/antibody fragments (like nanobodies) offer high affinity and specificity for GPCR modulation.
- Multivalent antibody-based conjugates (e.g., peptide-antibody constructs, nanobody fusions, small molecule-nanobody conjugates) enable potent and specific GPCR activation, receptor assembly engagement, and tailored biased signaling.
- These conjugates represent next-generation therapeutic tools for GPCRs, with emerging bioconjugation and antibody engineering expanding their utility.