Antimicrobial peptide-derived lipid nanoparticles enable lung-targeted mRNA therapy for multidrug-resistant bacterial pneumonia - PubMed
3 hours ago
- #multidrug-resistant bacteria
- #lipid nanoparticles
- #mRNA therapeutics
- Developed antimicrobial peptide-derived lipid nanoparticles for lung-targeted mRNA therapy against multidrug-resistant bacterial pneumonia.
- The nanoparticles deliver mRNA encoding cathelicidin, a host defense peptide with broad antimicrobial activity.
- Enables coordinated killing of both intracellular and extracellular bacteria, overcoming treatment barriers.
- Single systemic administration in mice results in robust lung accumulation, reduced bacterial burden, suppressed inflammation, improved outcomes, and increased survival.
- Offers a novel, generalizable framework for mRNA-based antimicrobials against resistant respiratory infections.