Shared genetic architecture between ADHD and intelligence varies across ADHD subtypes - PubMed
3 hours ago
- #genetic architecture
- #ADHD subtypes
- #intelligence
- ADHD and intelligence show significant negative genetic correlations across all subtypes (rg from -0.3442 to -0.4205).
- Substantial genetic overlap exists via polygenic overlap, local genetic correlations, and variant-level associations, with 184 shared loci identified (64 novel).
- Shared loci reveal distinct biological pathways: childhood ADHD linked to early neurodevelopment, late-diagnosed ADHD to synapse and neuronal signaling.
- Mendelian randomization suggests bidirectional associations, with stronger evidence for intelligence influencing ADHD risk.
- Findings indicate subtype-specific genetic architectures, highlighting cognitive heterogeneity in ADHD and informing risk stratification.