Differential effects of prior versus concomitant Steroid and Antibiotic Treatment on Immunotherapy Efficacy - A Pooled Analysis of the RAMONA, INTEGA, OPTIM, ELDORANDO, FORCE, TITAN-RCC and TITAN-TCC
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- Prior antibiotic use (before study start) was associated with shorter overall survival (OS) and progression-free survival (PFS) in patients receiving immune checkpoint inhibitor (ICI) therapy.
- Concomitant antibiotic use (during study) did not significantly affect OS or PFS in the same patient cohort.
- Concomitant steroid use was linked to longer PFS, possibly due to its association with managing immune-related adverse events (irAEs).
- The study analyzed pooled data from seven trials involving various solid tumors, including head and neck cancer, NSCLC, and renal cell carcinoma.
- Findings suggest that prior antibiotic use may reduce ICI efficacy, highlighting the potential role of microbiome diversity in treatment response.