The microbiota-tryptophan-brain axis in neurodegenerative diseases: pathogenic mechanisms, disease-specific roles, and translational therapeutics - PubMed
3 hours ago
- #microbiota-gut-brain axis
- #tryptophan metabolism
- #neurodegenerative diseases
- The microbiota-tryptophan-brain axis is key in neurodegenerative diseases (NDDs) like Alzheimer's and Parkinson's.
- Tryptophan metabolites from gut microbiota (indole, kynurenine, serotonin) affect the CNS via the microbiota-gut-brain axis.
- These metabolites influence neuroinflammation, oxidative stress, and protein aggregation through immune and barrier functions.
- Disease-specific roles are explored for Alzheimer's, Parkinson's, ALS, and Huntington's disease.
- Therapeutic strategies include nutrition, probiotics, fecal transplants, and metabolite-based drugs.
- Future research aims to clarify mechanisms, develop biomarkers, and enable personalized NDD treatments.