Placental nicotinamide adenine dinucleotide modulates the timing of labor - PubMed
3 hours ago
- #NAD+
- #placental metabolism
- #labor timing
- Labor timing is regulated by prostaglandin signaling in gestational tissues.
- Placental NAD+ levels influence gestational length by acting as a cofactor for 15-hydroxy prostaglandin dehydrogenase, which suppresses prostaglandins.
- Depletion of placental NAD+ triggers labor onset, while augmentation extends gestation, including in preterm labor models.
- Metabolic exhaustion in the placenta may be a key factor initiating labor.
- Findings suggest potential therapies for preterm labor and optimizing labor induction.