Epigenetic noise in the aging brain: tuning neuronal vulnerability to neurodegeneration - PubMed
2 hours ago
- #Epigenetics
- #Aging Brain
- #Neurodegeneration
- Epigenetic noise in the aging brain increases neuronal vulnerability to neurodegeneration.
- Aging disrupts epigenetic regulation, causing noise in DNA methylation, histone modifications, and chromatin accessibility.
- Epigenetic alterations are active contributors to neuronal vulnerability across brain regions and cell types.
- The review links epigenetic noise to diseases like Alzheimer's, Parkinson's, ALS, and Huntington's.
- Strategies to stabilize the aging neuronal epigenome are emerging as potential interventions.