Membrane ATG8ylation in secretory autophagy - PubMed
3 hours ago
- #ATG8ylation
- #secretory autophagy
- #unconventional protein secretion
- Mammalian Atg8-family (ATG8) proteins are essential for autophagic degradation and non-degradative processes, including secretory autophagy.
- Secretory autophagy uses ATG8 conjugated to membranes to specify and traffic molecules for extracellular release.
- The review presents a framework for classifying secretory autophagy pathways based on membrane ATG8ylation at vesicular intermediates.
- It discusses the roles of these pathways in physiology and disease.