A CD4+ T cell-fibroblast crosstalk exacerbates autoimmunity in a mouse model of primary Sjögren disease - PubMed
3 hours ago
- #Autoimmunity
- #Fibroblast Crosstalk
- #Sjögren Disease
- CD153+CD4+ T cells are identified as critical drivers of inflammation in early stages of primary Sjögren disease (pSjD) in a mouse model.
- A CD153+CD4+ T cell-CD30+ tissue-resident fibroblast interaction promotes fibroblast proliferation and chemokine secretion, amplifying immune cell infiltration and autoimmune response.
- Deletion of CD153 in CD4+ T cells or neutralization of fibroblast-derived chemokines reduces lymphocytic infiltration and halts autoimmune-like pathology in the model.
- The CD153-CD30 axis correlates with disease severity in human patients, suggesting a therapeutically targetable pathway for pSjD.