Associations of cumulative exposure and dynamic trajectories of the combined atherogenic and frailty index with incident cardiometabolic multimorbidity: a longitudinal analysis based on the China Heal
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- #cardiometabolic multimorbidity
- #frailty index
- #atherogenic index
- This study analyzed data from the China Health and Retirement Longitudinal Study (CHARLS) to examine associations between a combined atherogenic index of plasma-frailty index (AIPFI) and incident cardiometabolic multimorbidity (CMM).
- Baseline analysis included 7,995 participants, with 747 incident CMM cases over a median 9-year follow-up. Higher AIPFI quartiles progressively increased CMM risk, with the highest quartile showing an adjusted hazard ratio of 2.46.
- Longitudinal analysis of 4,483 participants showed that those with persistently high and increasing AIPFI values had a higher CMM risk (HR 1.54). Cumulative AIPFI exposure was also positively associated with CMM incidence.
- Nonlinear relationships were found between baseline and cumulative AIPFI and CMM risk. SHAP analysis identified hypertension, heart disease, and AIPFI as key predictors.
- The findings suggest that monitoring AIPFI longitudinally could improve CMM risk prediction and inform prevention strategies in population health evaluations.