A damage accumulation model identifies distinct aging regimes across species
4 hours ago
- #aging regimes
- #lifespan prediction
- #damage accumulation
- The saturating removal (SR) model of damage accumulation is used to analyze survival data across multiple species.
- Damage production rate is the strongest predictor of lifespan differences, spanning seven orders of magnitude.
- Two aging regimes identified: ballistic aging (production dominates removal) in short-lived species and quasi-steady-state aging (production balanced by removal) in longer-lived mammals.
- Certain parameter combinations, like noise and removal timescale ratios, are conserved across mammals.
- Yeast replicative aging shows negligible removal, fitting the ballistic aging regime.
- The study suggests that lifespan extension interventions should focus on reducing damage production rather than solely enhancing removal or tolerance.