Why Osteosarcopenia Matters: Clinical and Investigative Implications - PubMed
3 days ago
- #geriatric health
- #bone-muscle crosstalk
- #osteosarcopenia
- Osteosarcopenia is the combination of osteoporosis and sarcopenia, leading to functional decline, falls, and fragility fractures.
- Its pathophysiology involves mechanical, metabolic, and hormonal factors, with changes like chronic inflammation and disrupted tryptophan metabolism.
- Diagnosis combines bone mineral density assessment via Dual-energy X-ray Absorptiometry with sarcopenia evaluations based on international consensus guidelines.
- Management includes osteoporosis medications, resistance exercise, adequate protein intake, and supplements like vitamin D, calcium, and creatine.
- Emerging treatments include hormonal modulators, anti-inflammatory agents, and cell-based interventions.
- The condition increases risks of falls, fractures, disability, and mortality, necessitating a comprehensive, dual-targeted approach for effective care.