Rejuvenating Inter-organellar Communication Via Mitophagy in Ageing and Neurodegeneration - PubMed
3 hours ago
- #Ageing
- #Neurodegeneration
- #Mitophagy
- Mitophagy is essential for maintaining inter-organelle communication between mitochondria, ER, and lysosomes.
- Impaired mitophagy leads to ER fragmentation, lysosomal dysfunction, and disrupted calcium homeostasis.
- Urolithin A (UA) restores mitophagy by promoting calcium release from the ER and uptake into mitochondria.
- UA activates mitochondrial fission via DRP-1 and mitochondrial biogenesis via the CaMKII-Nrf2 pathway.
- UA increases ER-mitochondrial contact sites (MAMs) and lysosomal activity, improving cellular health.