HLA micropolymorphisms confine neoantigen conformational adaptability and guide T cell receptor selectivity - PubMed
3 hours ago
- #T cell receptor
- #HLA micropolymorphisms
- #neoantigen dynamics
- HLA micropolymorphisms affect T cell receptor specificity by altering the conformational adaptability of neoantigen complexes, not by changing peptide binding or static structures.
- The study uses HLA-A*03:01 and HLA-A*03:02 alleles to show how micropolymorphisms prevent TCR binding through a network of interactions controlling peptide/HLA dynamics.
- High-resolution HLA typing is emphasized as crucial for immunology research and antigen-specific immunotherapy due to its impact on immune recognition.