Coordinated IFN-γ/TNF Axis Drives Selective Loss of Activated Enteric Glia in Inflammatory Bowel Diseases - PubMed
2 hours ago
- #IFN-γ/TNF axis
- #enteric glial cells
- #inflammatory bowel disease
- Novel markers of enteric glial cell (EGC) activation, such as osteopontin (SPP1), are identified, particularly enriched in ulcerative colitis.
- Activated EGCs in inflammatory bowel diseases (IBD) undergo selective loss via necroptosis, driven by phosphorylation of MLKL.
- Coordinated IFN-γ and TNF stimulation induces MLKL-dependent necroptosis in EGCs, while Caspase-8 acts as a survival checkpoint.
- In mouse models, acute inflammation triggers EGC activation and necroptosis, impairing intestinal motility.
- Targeting glial survival mechanisms may offer a new therapeutic strategy for IBD-associated dysmotility.