Dissecting Immune Cell Ferroptosis via Single-Cell Multi-Omics Identifies RPL8 as a Potential Therapeutic Target for Depression - PubMed
3 hours ago
- #depression
- #ferroptosis
- #RPL8
- Identified 42 ferroptosis genes linked to depression via Mendelian randomization.
- Ribosomal protein RPL8 emerged as a key protective factor across cohorts.
- RPL8 expression is enriched in blood and immune cells.
- Single-cell eQTL analysis showed RPL8's effect mediated through 11 immune cell subtypes.
- Molecular docking predicted high-affinity binding between RPL8 and ferroptosis ligand Ncoa4-9A.
- Proposed the 'immune-ribosome-ferroptosis' axis as a therapeutic direction for depression.