Sustained activation of M1 microglia by oligomerized alpha-synuclein released from dopaminergic neuronal damage through CD11b/Src/Erk/NOX2 axis after Paraquat exposure - PubMed
3 days ago
- #neuroinflammation
- #alpha-synuclein
- #microglia activation
- Paraquat (PQ) exposure induces alpha-synuclein (α-syn) aggregation and release from dopaminergic neurons.
- Released α-syn activates microglia via binding to CD11b, triggering the Src/Erk/NOX2 signaling pathway.
- Activation of NOX2 leads to ROS production and sustained M1 microglial polarization, exacerbating neuroinflammation.
- Inhibition of CD11b with RGD peptide reduces NOX2 activation and attenuates microglial inflammatory responses.
- Findings reveal a mechanism linking environmental toxin exposure to neuroinflammation in Parkinson's disease progression.