Comparative associations of LDL-C, Lp(a), hsCRP, and IL-6 with cardiovascular risk: Insights from the United Kingdom (UK) biobank and the multi-ethnic study of atherosclerosis (MESA) - PubMed
3 hours ago
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- #biomarkers
- #cardiovascular risk
- IL-6 showed the strongest association with atherosclerotic cardiovascular disease (ASCVD) risk when compared to LDL-C, Lp(a), and hsCRP in both UK Biobank and MESA cohorts.
- In fully adjusted models, IL-6 had hazard ratios of 1.67 in UK Biobank and 1.60 in MESA for top versus bottom quartiles, indicating significant independent risk.
- Lp(a) and hsCRP also showed associations with ASCVD, but were generally weaker than IL-6, with LDL-C showing modest or inconsistent associations across cohorts.
- The study suggests IL-6 may be a key driver of ASCVD, highlighting its potential for risk prediction and as a therapeutic target in primary prevention.