Amphiregulin drives EGFR-dependent genome stability in colorectal cancer and represents a targetable vulnerability - PubMed
3 hours ago
- #Amphiregulin
- #Genome Stability
- #Colorectal Cancer
- Amphiregulin (AREG) is an EGFR ligand highly expressed in colorectal cancer (CRC) tumors.
- AREG translocates to the nucleus, regulating DNA replication and repair, and its depletion causes cell cycle arrest and reduced proliferation.
- In xenograft models, AREG knockout reduces tumor growth and enhances effects when combined with EGFR inhibition.