Targeting STAT3-mediated lipid metabolism reprogramming overcomes chemoresistance in acute myeloid leukemia - PubMed
4 hours ago
- #chemoresistance
- #STAT3
- #lipid metabolism
- Chemoresistance in acute myeloid leukemia (AML) involves STAT3-mediated reprogramming of lipid metabolism, enhancing lipid synthesis and catabolism.
- Inhibiting STAT3 with W1307 disrupts lipid homeostasis, causing lipid accumulation, ROS increase, and mitochondrial dysfunction, overcoming chemoresistance.
- Combining STAT3 inhibition with Ara-C enhances anti-tumor effects and re-sensitizes resistant AML cells by inducing lipotoxicity.