SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis - PubMed
4 hours ago
- #Copper Trafficking
- #Cuproptosis
- #SLC25A3
- SLC25A3 exports mitochondrial copper to the intermembrane space for cytochrome c oxidase (CcO) metalation and prevents cuproptosis.
- Loss of SLC25A3 reduces mitochondrial copper content and CcO activity; bypassing it with elesclomol leads to toxic copper retention and cuproptosis.
- SLC25A3 functions as a copper exporter, critical for CcO function and regulating susceptibility to cuproptosis.