Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) maintains muscle progenitor identity by stabilizing the Ppp1r1b-lncRNA-PRC2 complex - PubMed
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- #Epigenetics
- #RNA Binding
- #Muscle Regeneration
- hnRNPA1 stabilizes the interaction between Ppp1r1b-lncRNA and PRC2 during myogenesis.
- Knockdown of hnRNPA1 reduces H3K27me3 levels, increases expression of muscle-specific genes, and disrupts the undifferentiated state.
- The hnRNPA1-Ppp1r1b-lncRNA-PRC2 axis is conserved in human cells and may be a therapeutic target for muscle regeneration.