Structural decomposition enables multi-omics dissection of common and organ-specific aging - PubMed
3 days ago
- #multi-omics
- #biomarkers
- #aging
- Proposes a structural decomposition framework to separate Common BAG and Organ-Specific BAGs from biological age gaps across seven organs in a large cohort.
- Demonstrates that the model improves predictions of lifespan, healthspan, and organ-specific diseases compared to undecomposed methods.
- Identifies novel genetic loci and reveals modular aging architecture through multi-omics integration, highlighting cross-tissue and organ-restricted pathways.
- Discovers organ-specific pro-aging drug effects and sex differences in aging trajectories using the framework.
- Integrates findings into HONOR, an open-access atlas for structural aging and multi-omics translation.