Host-virus determinants of Ebola virus persistence in a human cerebral organoid model - PubMed
2 hours ago
- #viral persistence
- #Ebola virus
- #cerebral organoid
- Ebola virus (EBOV) causes Ebola virus disease (EVD) with high fatality rates, and survivors may experience persistent viral infection in immune-privileged tissues like the central nervous system (CNS).
- A human cerebral organoid model was developed to study host and viral determinants of EBOV CNS persistence, revealing persistence for 120 days through continuous infection of astrocytes, neurons, and microglia.
- Persistence involved the emergence of EBOV defective viral genomes and subvariants, cell-to-cell transmission, activation of cell-specific innate immunity, and late brain organoid inflammation, suggesting that EBOV persistence in immune-privileged niches drives local inflammation.