Chemotherapy-induced cell cycle arrest is associated with increased claudin-18 isoform 2 expression and enhanced zolbetuximab-mediated cytotoxicity in gastric cancer - PubMed
2 days ago
- #Gastric Cancer
- #Chemotherapy Combination
- #Claudin-18 Isoform 2
- Chemotherapy upregulates CLDN18.2 expression in gastric cancer tissues and cell lines via transcriptional mechanisms.
- Cell cycle arrest, induced by chemotherapeutic agents or CDK inhibitors, enhances CLDN18.2 expression.
- Increased CLDN18.2 expression boosts zolbetuximab-mediated antibody-dependent cellular cytotoxicity against gastric cancer cells.
- The study supports combining zolbetuximab with chemotherapy or CDK inhibitors for gastric cancer treatment.