Genetic analysis of pyrimidine biosynthetic enzymes in Plasmodium falciparum - PubMed
2 hours ago
- #malaria
- #Plasmodium falciparum
- #pyrimidine biosynthesis
- Plasmodium falciparum relies entirely on de novo pyrimidine synthesis for essential nucleotides.
- The study investigates three enzymes: PfATC, PfCPSII, and PfDHO, revealing their essential roles.
- PfATC's N-terminal extension is not localized to the apicoplast but is important for parasite growth.
- PfCPSII, with Plasmodium-specific insertions, is also essential for parasite proliferation.
- PfDHO deletion in uracil-salvaging parasites leads to auxotrophy, confirming its essential function.
- Multiple vulnerable nodes in the pyrimidine biosynthesis pathway highlight potential drug targets.