Remodeling of the immune-metabolic landscape triggered by long-term high-altitude exposure - PubMed
3 hours ago
- #single-cell omics
- #immune-metabolic remodeling
- #high-altitude adaptation
- Long-term high-altitude exposure triggers immune-metabolic remodeling with a strategy of 'innate activation and adaptive suppression'.
- Neutrophils show enhanced maturation and phagocytosis, while adaptive immunity is suppressed, including reduced B cell function and T cell responsiveness.
- Metabolic shifts in steroid and amino acid metabolism occur systemically and are linked to immune remodeling.
- Multi-omics integration reveals conserved upregulation of the glycolysis-TCA-OXPHOS axis across immune lineages, confirmed in a hypobaric hypoxia mouse model.
- The findings suggest a mutual regulatory relationship between immune and metabolic states, providing a molecular basis for high-altitude adaptation research.