Does neoadjuvant therapy reduce pancreatic fistula after pancreatoduodenectomy and distal pancreatectomy?-a systematic review and meta-analysis - PubMed
4 hours ago
- #pancreatic fistula
- #pancreatic resection
- #neoadjuvant therapy
- Neoadjuvant therapy (NAT) significantly reduces postoperative pancreatic fistula (POPF) rates after pancreatoduodenectomy (Whipple procedure).
- Pancreatic texture becomes harder after NAT, which is linked to lower POPF risk.
- No significant differences were found between NAT and upfront surgery groups regarding pancreatic duct size or BMI.
- The exact mechanisms of pancreatic texture change during NAT remain unclear.
- Tailoring treatment based on predicted tumor response to NAT could improve surgical outcomes.