Herb-derived immunometabolic modulators: traditional Chinese medicine at the crossroads of metabolism and antitumor immunity - PubMed
3 hours ago
- #Immunometabolism
- #Tumor Microenvironment
- #Traditional Chinese Medicine
- Traditional Chinese Medicine (TCM) is reviewed for its role in immunometabolic therapy, focusing on how it influences tumor metabolism and antitumor immunity.
- Four key immunometabolic axes are identified: glycolysis-lactate, mitochondrial stress and immunogenic cell death (ICD), lipid-bile-acid signaling, and redox balance.
- Various TCM-derived interventions, such as Astragalus-based formulas, ginsenosides, berberine, and nanoplatforms, are shown to modulate these axes to enhance immune responses and metabolic fitness in the tumor microenvironment.
- The review links these immunometabolic effects to traditional TCM doctrines like Fuzheng Quxie, proposing a framework for integrating TCM into precision cancer treatment.
- TCM is highlighted as a potential co-therapy to convert 'cold' tumors to 'hot', improve responses to conventional therapies, and enhance treatment tolerance, with future research needs including mechanistic studies and clinical trials.