A quest for a histaminergic or orexinergic biomarker for sudden infant death syndrome - PubMed
4 hours ago
- #Histamine
- #Orexin
- #SIDS
- SIDS occurs mainly during sleep in infants aged 2-6 months, suggesting issues with arousal pathway maturation.
- CSF orexin levels were higher in SUDI infants aged 2-6 months, but no overall difference was found between groups.
- Histamine and tele-methylhistamine levels were elevated in SUDI, likely due to postmortem release.
- Orexin neuron numbers increased in the rostral hypothalamic region in SIDS compared to explained deaths.
- Histamine neuron numbers remained unchanged between SIDS and explained death cases.
- Increased orexin activity in SIDS may be a compensatory response to arousal deficits, stress, or hypoxia.
- The study suggests orexin as a potential biomarker for SIDS risk, while histamine's role is unclear and requires more sensitive biomarkers.