CYLD-mediated lysine63 deubiquitination regulates synaptic transmission and autophagy to mitigate age-related sequelae - PubMed
3 hours ago
- #neurobiology
- #autophagy
- #ageing
- CYLD-1, a lysine63-specific deubiquitinase, is essential for physiological lifespan in C. elegans.
- Neuronal CYLD-1 supports cholinergic neurotransmission and GABAergic synapse integrity, maintaining locomotory capacity and cognitive functions like learning and memory.
- The deubiquitinase activity of CYLD-1 is necessary for upholding cholinergic neurotransmission and lifespan.
- CYLD-1 regulates the organization of autolysosomal and lysosomal networks in both neurons and peripheral tissues in vivo.
- CYLD-1 optimizes neural activity and behavioral outcomes to improve organismal fitness and survival, mitigating age-related sequelae.