Alzheimer's Disease Co-Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis - PubMed
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- #Cognitive Impairment
- #Amyotrophic Lateral Sclerosis
- #Alzheimer's Disease
- The study investigated the association between Alzheimer's disease (AD) related pathological changes and cognitive impairment in amyotrophic lateral sclerosis (ALS).
- Biomarkers including cerebrospinal fluid (CSF) total-tau, phosphorylated-tau, beta-amyloid, and plasma TDP-43 and neurofilament light chain were analyzed in 192 ALS or ALS-frontotemporal dementia patients and 100 healthy controls.
- Patients with ALS, especially those with cognitive impairment (ALSci) or ALS-FTD, showed elevated AD-related biomarkers compared to healthy controls.
- CSF p-tau and total-tau levels were strongly linked to domain-specific cognitive performance, while plasma TDP-43 and NfL showed weak or no association.
- Postmortem data indicated that temporal and hippocampal TDP-43 burden, rather than overall TDP-43 or ABC scores, was associated with cognitive dysfunction.
- The findings suggest tau-related CSF biomarkers are associated with cognitive deficits in ALS, but TDP-43 pathology may have an even stronger relationship postmortem.