Attenuated FTO induces necroptosis of alveolar epithelium via the m6A/CYP1B1/ROS/MLKL axis to promote the aggravation of pulmonary emphysema - PubMed
3 hours ago
- #Oxidative Stress
- #COPD
- #Necroptosis
- FTO (fat mass and obesity-associated protein) is reduced in alveolar type II cells in COPD patients and smoke-exposed mice.
- FTO deficiency leads to increased m6A modification, stabilizing CYP1B1 mRNA, raising ROS levels, and activating MLKL necroptosis.
- This FTO-m6A-CYP1B1-ROS-MLKL axis drives alveolar epithelial necroptosis and emphysema progression.
- Silencing CYP1B1 or using antioxidant NAC reduces ROS and necroptosis, alleviating emphysema.
- FTO is identified as a target for redox-focused interventions in COPD-related emphysema.