The follicular microbiome in hair-follicle-associated inflammatory diseases: A systematic review - PubMed
4 hours ago
- #hair disorders
- #systematic review
- #microbiome
- The review examined the bacterial microbiome of hair follicles in inflammatory hair-follicle-related diseases.
- It included 55 studies (2011 patients from 19 countries) published between 2007 and August 2024.
- Methodologies varied widely across studies in sampling, storage, DNA extraction, sequencing, and analysis.
- Recurrent alterations involved Cutibacterium and Staphylococcus genera across multiple diseases.
- Staphylococcus generally showed increased relative abundance, especially in scarring alopecias, seborrheic dermatitis/dandruff, and acne.
- Cutibacterium abundance was reduced in seborrheic dermatitis/dandruff but appeared more prevalent in androgenetic alopecia.
- Findings for Cutibacterium in scarring alopecias and acne were inconsistent, while results in alopecia areata and rosacea were inconclusive.
- Hidradenitis suppurativa suggested enrichment of anaerobic opportunists like Porphyromonas and Prevotella.
- The causal significance of observed microbiome shifts remains unclear, necessitating larger, standardized studies with functional analyses.