Minoxidil May be a Partial Agonist of Estrogen Receptor Alpha - PubMed
4 hours ago
- #Minoxidil
- #Estrogen Receptor Alpha
- #Androgenetic Alopecia
- Minoxidil (MX) is commonly used to treat androgenetic alopecia (AGA).
- Recent evidence suggests MX may directly bind to the Androgen Receptor (AR) and act as an anti-androgen.
- Researchers investigated whether MX also exhibits estrogenic activity.
- Methods included estrogen-dependent cell lines, tryptophan emission, and computational docking.
- Preliminary results indicate MX may be a partial agonist of Estrogen Receptor α (ERα).
- The study used SwissDock 2024 for docking and referenced molecular basis of ER agonism/antagonism.
- No conflicts of interest were declared by the authors.