Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells - PubMed
3 hours ago
- #ovarian cancer
- #B cells
- #lymph nodes
- High-grade serous ovarian cancer (HGSOC) patients with B cells in tumors have better prognoses.
- Tumor-draining lymph nodes (TDLNs) lack active germinal centers and are dominated by memory B cells (MBCs) reactive to tumor cells.
- Memory B cells in TDLNs are clonally linked to those within tumors, suggesting they contribute to anti-tumor responses.
- Increased DC-SIGN+ macrophages in TDLNs correlate with fewer germinal center B cells, indicating a possible regulatory role.