Kidney Transplantation in Two Highly Sensitized Candidates after CAR T-Cell Therapy - PubMed
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- #Desensitization
- #CAR T-Cell Therapy
- #Kidney Transplantation
- Chimeric antigen receptor (CAR) T-cell therapy targeting CD19 and B-cell maturation antigen (BCMA) was explored as a desensitization method for kidney transplantation in highly sensitized candidates.
- A multicenter phase 1 clinical trial included two patients with end-stage kidney disease and a calculated panel-reactive antibody score of ≥99.9%.
- The study, registered under NCT06056102, aimed to evaluate the safety and efficacy of this therapy to eliminate cellular sources of preformed anti-HLA antibodies before transplantation.