Association between preoperative metformin exposure and postoperative nausea and vomiting in patients undergoing general anaesthesia: a protocol for a prospective observational cohort study in a Chine
3 hours ago
- #cohort study
- #metformin
- #PONV
- The study investigates whether preoperative metformin use is linked to reduced postoperative nausea and vomiting (PONV) in adults under general anaesthesia, based on metformin's potential to increase GDF-15 levels, a biomarker inversely related to PONV risk.
- It is a single-centre, prospective, observational cohort study aiming to enroll 909 patients from December 2025 to December 2028, divided into exposed (metformin users, n=303) and non-exposed groups (n=606) in a 1:2 ratio.
- The primary outcome is PONV incidence within 120 hours post-surgery, with secondary outcomes including early/late PONV phases, severity, rescue antiemetic use, quality of recovery assessments, potential biomarkers, and long-term survival rates up to 5 years.
- Ethics approval was granted by the Sixth Affiliated Hospital of Sun Yat-sen University, with an amendment adding a 30-day quality of recovery assessment but not altering primary outcomes or sample size.
- Results will be disseminated through scientific conferences and peer-reviewed journals, with no declared conflicts of interest, and the study is registered under NCT07244575.