Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis - PubMed
4 hours ago
- #oligodendrocyte
- #Piezo2
- #multiple sclerosis
- Piezo2, a mechanosensitive ion channel, is expressed in late differentiated oligodendrocytes (OLs) in the murine optic nerve.
- OL-specific Piezo2 deficiency leads to age-dependent motor impairment and disrupted myelin compaction in small-caliber optic nerve axons.
- Piezo2 regulates myelin compaction and white matter integrity in mature OLs, as shown by differential gene expression analysis.
- PIEZO2 expression is reduced in optic nerve lesion areas from multiple sclerosis patients, suggesting a role in small-caliber fiber vulnerability.
- The study identifies Piezo2 as an age-related regulator of OL function and myelin integrity, with implications for multiple sclerosis.