TPM1 drives cytoskeleton-immunometabolism coupling and LGALS9/CD45-mediated neuroinflammatory propagation in retinitis pigmentosa - PubMed
an hour ago
- #immunometabolism
- #neuroinflammation
- #retinal degeneration
- TPM1 is identified as a key regulator linking cytoskeletal changes with immune metabolism in retinitis pigmentosa (RP).
- Genetic removal of TPM1 reduces microglial activation and protects vision, while its overexpression triggers sustained inflammation through multiple interconnected pathways.
- TPM1 promotes AP-1 hyperactivation, leading to SASP via MAPK signaling, reduces phagocytosis, disrupts lipid metabolism causing lipid droplet accumulation, and uses LGALS9/CD45 signaling to spread inflammation.
- Targeting TPM1, especially the LGALS9/CD45 axis, could offer new therapeutic strategies to break neuroinflammatory cycles while maintaining retinal health.