Seizure worsening and sodium channel blockers in HCN1-related epilepsies: A case series - PubMed
3 hours ago
- #Sodium channel blockers
- #Seizure worsening
- #HCN1-related epilepsy
- Pathogenic HCN1 variants are linked to various epilepsies, including drug-resistant developmental and epileptic encephalopathies.
- Sodium channel blocker antiseizure medications (phenytoin, lamotrigine, oxcarbazepine, lacosamide) worsened seizures in seven patients with gain-of-function HCN1 variants.
- Discontinuation of sodium channel blockers led to clinical improvement in all cases.
- The findings highlight a clinically actionable gene-drug interaction, supporting mechanism-based antiseizure medication selection.
- This evidence aids precision treatment strategies and helps avoid harmful therapies in children with HCN1-related epilepsies.