GWAS on short tandem repeats identifies genetic mechanisms in Alzheimer's disease - PubMed
2 hours ago
- #Short Tandem Repeats
- #Alzheimer's Disease
- #GWAS
- GWAS systematically analyzes short tandem repeats (STRs) in Alzheimer's disease using ~330,000 individuals from UK Biobank.
- Identifies 15 independent loci with genome-wide significant associations, including novel signals near SNX32 and WSB1 genes.
- Finds that STRs are the lead signal at ABCA7 and contribute substantially to SNP-driven associations at HLA-DRB1, MINDY/ADAM10, and APOE.
- Estimates STRs account for at least 3% of Alzheimer's disease phenotypic variance in the dataset.
- Suggests STRs may impact Alzheimer's disease risk by influencing gene expression, based on alignment with methylation and transcriptome data.