The ubiquitin-proteasome system: A master regulator of cell cycle progression - PubMed
3 hours ago
- #E3 Ligases
- #Cell Cycle Regulation
- #Ubiquitin-Proteasome System
- The ubiquitin-proteasome system (UPS) regulates protein homeostasis through ubiquitin-mediated processes.
- UPS controls key cell cycle regulators like cyclins, CDK inhibitors, and checkpoint proteins.
- E3 ubiquitin ligases, such as APC/C and SCF complexes, ensure timely degradation for proper cell cycle transitions.
- UPS dysregulation contributes to diseases like cancer via aberrant stabilization or premature degradation of regulators.
- The review covers UPS mechanisms, key enzymes, and therapeutic potential in cell cycle-associated disorders.