Myeloid Piezo1 Drives Cardiac Repair Through Orai1-Rac1-Dependent Efferocytosis - PubMed
3 hours ago
- #Myocardial infarction
- #Efferocytosis
- #Cardiac repair
- Myeloid Piezo1 deletion improves cardiac function and reduces fibrosis post-myocardial infarction.
- Piezo1 deficiency increases anti-inflammatory cytokine production early after myocardial infarction.
- Mechanistically, Piezo1 deletion enhances Orai1 expression and calcium influx in macrophages.
- This leads to enhanced macrophage efferocytosis via Rac1 activation and cytoskeletal remodeling.
- Piezo1 deletion also promotes lysosomal acidification and phagosome maturation for efficient apoptotic cell degradation.
- A Piezo1-Orai1-Rac1 axis regulates macrophage efferocytosis and lysosomal maturation following myocardial infarction.