Asymmetric structural transitions in the icosahedral organization of Eastern equine encephalitis virus - PubMed
a day ago
- #alphavirus
- #structural biology
- #viral fusion
- Delivery of viral genome into host cells is critical for infection, involving membrane fusion under acidic conditions.
- Structural changes in glycoprotein organization are required for fusion, but have been elusive due to transient states and heterogeneity.
- The study provides snapshots of conformational changes in Eastern equine encephalitis virus glycoproteins and nucleocapsid core at 40°C or pH 5.6.
- Insights are gained into pre-fusion structural transitions and the molecular basis of a pan-alphavirus epitope recognized by a human antibody.