FGFR1-ETV1-CXCL1 signaling in dermal fibroblast orchestrates fibroblast-associated itch - PubMed
3 hours ago
- #Fibroblast
- #Signaling Axis
- #Pruritus
- A study identified the FGFR1-ETV1-CXCL1 signaling axis in dermal fibroblasts as crucial for fibroblast-associated itch.
- Chemogenetic activation of dermal fibroblasts induced scratching behaviors in mice, while inhibition reduced itch responses.
- ETV1 nuclear translocation in fibroblasts, regulated by PARP1, is key to activating this pruritogenic signaling pathway.
- Conditional knockout of ETV1 in mice confirmed the essential role of this signaling in mediating itch.
- The findings establish a link between fibroblast plasticity and somatosensory disorders, highlighting a new therapeutic target.