Huanglian Wendan ameliorates depression via gut-brain axis-related PPAR-α/allo pathways - PubMed
4 hours ago
- #neuroinflammation
- #depression mechanisms
- #traditional Chinese medicine
- Huanglian Wendan decoction (HLWD) is traditionally used for insomnia and irritability, with potential for treating depression.
- HLWD improved depressive-like behaviors in mice and enhanced neurogenesis markers while reducing inflammation.
- It protected the intestinal mucosal barrier and reduced inflammatory responses in both colon and hippocampus.
- RNA sequencing showed enrichment of the PPAR signaling pathway in the colon; HLWD upregulated PPAR-α levels there.
- HLWD increased allopregnanolone in the hippocampus via peripheral circulation, and PPAR-α antagonist GW6471 reversed these effects.
- HLWD may alleviate depression by modulating the gut-brain axis via PPAR-α and allopregnanolone pathways.